Architect and contractor R. E. Bost completed an estimated 60 building projects in Natchez throughout his career from 1890-1936. The Charles V. Patterson House, located on South Union Street, remains as his finest example of the Queen Anne style. Completed for the family of Charles V. Patterson in late 1898, the residence reflected the growing wealth of a new Natchez merchant class. Patterson was a partner in Chamberlain and Patterson Staple and Fancy Dry Goods Store on Main Street. As Natchez entered the twentieth-century, new wealth coupled with new architectural trends transformed the city into much of what it is today.

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